Patricia Wettig is an American actress and playwright.

She is best known for her role as Nancy Weston in the television series Thirtysomething (1987–1991), for which she received a Golden Globe Award and three Primetime Emmy Awards.

After her breakthrough role in Thirtysomething, Wettig has appeared in a number of films, include Guilty by Suspicion (1991), City Slickers (1991), City Slickers II: The Legend of Curly's Gold (1994), and The Langoliers (1995).

She returned to television playing a leading role in the 1995 short-lived drama Courthouse and later played Caroline Reynolds in the Fox drama Prison Break (2005–2007) and Holly Harper in the ABC family drama Brothers & Sisters (2006–2011).